Fourteen quinolizidine derivatives, structurally related to the alkaloids lupinine and cytisine and previously studied for other pharmacological purposes, were presently tested for. Alkaloids can exhibit a wide range of pharmacological activities, including stimulant, analgesic, antiarrhythmic, and antihypertensive effects. Some aporphine alkaloids, such as crebanine, were found to present arrhythmic activity and also higher toxicity.
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Quinidine has a direct myocardial depressant action.
A series of derivatives were synthesized by using three kinds of aporphine.
Membrane depressant drugs, beta adrenergic blocking agents, repolarization prolongators, calcium channel blockers. The document aims to teach students about medicinal chemistry principles related to. • natural drugs maintain calcium homeostasis via calcium channel regulation. It increases the refractory period, depresses contractility, depresses excitability and slows speed of conduction in cardiac muscle.
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